Small Navies Do Have a Place in Network-Centric Warfare

In “Small Navies and Network-Centric Warfare” (Naval War College Review, Spring 2003, pp. 1–16), Paul T. Mitchell asked if there is a place for small navies in the world of network-centric warfare. From my perspective as the program executive officer for the U.S. Coast Guard’s Integrated Deepwater System (IDS), the answer is a resounding “Yes!” The price of admission, however, is a network- centric system for C4ISR (command, control, communications, computers, intelligence, surveillance, and reconnaissance), modern air and surface plat- forms, and a well-established relationship with the U.S. Navy

Of Ghosts and Spaceships: Reclaiming Chinese National Identity through Science Fiction

This paper examines the extent to which Chinese science fiction literature has played a role in the reframing of Chinese national identity as one that is based in scientific and technological development. Specifically, whether the recent push during a 2007 conference in Chengdu for increased science fiction consumption has resulted in more scientific development and more positivist science fictional literature. The paper both evaluates the current state of science fiction in China and the potential impact of its narratives through an analysis of the historical context of the role of science fiction in China compared to the more modern usage as a promotional tool of national scientific development, and through a close reading of two contemporary, award-winning works of Chinese SF. This paper finds that despite efforts to encourage positivist SF as it had during the Mao regime, the resulting modern works are largely resistant to efforts of reframing national identity as “Scientific Chinese.” Instead of looking to the future, recent Chinese SF draws inspiration from the past, focusing on ghosts and tradition juxtaposed against oppressive technological development. The narratives reflect anxieties over a loss of cultural identity in the name of progress. What is left are stories that are anti-nationalistic, anti-progressive, and question the legitimacy of the role of technology in modern society. In conclusion, this paper finds propagandist techniques have not had the desired result on the narratives of Chinese SF in general. Instead, literature is responding to the world and is an outlet of anxieties of a changing world

Opposing roles for DNA replication initiator proteins ORC1 and CDC6 in control of Cyclin E gene transcription

Newly-born cells either continue to proliferate or exit the cell division cycle. This decision involves delaying expression of Cyclin E that promotes DNA replication. ORC1, the Origin Recognition Complex (ORC) large subunit, is inherited into newly-born cells after it binds to condensing chromosomes during the preceding mitosis. We demonstrate that ORC1 represses Cyclin E gene (CCNE1) transcription, an E2F1 activated gene that is also repressed by the Retinoblastoma (RB) protein. ORC1 binds to RB, the histone methyltransferase SUV39H1 and to its repressive histone H3K9me3 mark. ORC1 cooperates with SUV39H1 and RB protein to repress E2F1-dependent CCNE1 transcription. In contrast, the ORC1-related replication protein CDC6 binds Cyclin E-CDK2 kinase and in a feedback loop removes RB from ORC1, thereby hyper-activating CCNE1 transcription. The opposing effects of ORC1 and CDC6 in controlling the level of Cyclin E ensures genome stability and a mechanism for linking directly DNA replication and cell division commitment

Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein

The origin recognition complex (ORC) is an initiator protein for DNA replication, but also effects transcriptional silencing in Saccharomyces cerevisiae and heterochromatin function in Drosophila. It is not known, however, whether any of these functions of ORC is conserved in mammals. We report the identification of a novel protein, HBO1 (histone acetyltransferase binding to ORC), that interacts with human ORC1 protein, the largest subunit of ORC. HBO1 exists as part of a multisubunit complex that possesses histone H3 and H4 acetyltransferase activities. A fraction of the relatively abundant HBO1 protein associates with ORC1 in human cell extracts. HBO1 is a member of the MYST domain family that includes S. cerevisiae Sas2p, a protein involved in control of transcriptional silencing that also has been genetically linked to ORC function. Thus the interaction between ORC and a MYST domain acetyltransferase is widely conserved. We suggest roles for ORC-mediated acetylation of chromatin in control of both DNA replication and gene expression

Low-noise top-gate graphene transistors

We report results of experimental investigation of the low-frequency noise in the top-gate graphene transistors. The back-gate graphene devices were modified via addition of the top gate separated by 20 nm of HfO2 from the single-layer graphene channels. The measurements revealed low flicker noise levels with the normalized noise spectral density close to 1/f (f is the frequency) and Hooge parameter below 2 x 10^-3. The analysis of the noise spectral density dependence on the top and bottom gate biases helped us to elucidate the noise sources in these devices and develop a strategy for the electronic noise reduction. The obtained results are important for all proposed graphene applications in electronics and sensors.Comment: 9 pages, 4 figure

The relationship between fat mass and obesity associated gene polymorphism rs9939609 and resting cerebral blood flow in a midlife sample with overweight and obesity

Background: The single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity associated fat mass and obesity associated gene (FTO) gene has been linked with increased BMI in adults. Higher BMI has been associated with poor brain health and may exert deleterious effects on neurocognitive health through cerebral hypoperfusion. However, it is unclear if there is a relationship between the FTO genotype and cerebral perfusion, or whether FTO genotype moderates the effects of weight loss on cerebral perfusion. Using data from a randomized controlled behavioral weight loss trial in adults with overweight and obesity, we tested (1) whether carriers of the A allele for FTO rs9939609 demonstrate different patterns of resting cerebral blood flow (rCBF) compared to T carriers, and (2) whether the FTO genotype moderates the effects of weight loss on rCBF. We hypothesized that carriers of the A allele would exhibit lower resting CBF in frontal brain areas compared to T/T homozygotes at baseline, and that intervention-induced weight loss may partially remediate these differences. Methods and results: One hundred and five adults (75.2% female, mean age 44.9 years) with overweight or obesity were included in the analyses. These participants represent a subsample of participants in a larger randomized controlled trial (NCT01500356). A resting pseudo-continuous arterial spin labeling (pCASL) scan was acquired to examine rCBF. Age, sex, and BMI were included as covariates. At baseline, A carriers had greater rCBF in a diffuse cluster extending into the brainstem, motor cortex, and occipital lobe, but lower perfusion in the temporal lobe. We found no evidence that FTO moderated the effect of the intervention group assignment on rCBF changes. Conclusion: Overall, these results indicate that (a) individual variation in rCBF within a sample with overweight and obesity may be attributed to a common FTO variant, but (b) a weight loss intervention is effective at increasing rCBF, regardless of FTO genotype.R01 HL103646/HL/NHLBI NIH HHS/United States (PI, JJ)R01 DK095172/DK/NIDDK NIH HHS/United States (PI, KE

Terahertz Response of Field-Effect Transistors in Saturation Regime

We report on the broadband THz response of InGaAs/GaAs HEMTs operating at 1.63 THz and room temperature deep in the saturation regime. We demonstrate that responses show linear increase with drain-to-source voltage (or drain bias current) and reach very high values up to 170V/W. We also develop a phenomenological theory valid both in the ohmic and in the saturation regimes.Comment: 11 pages, 3 figure